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Your Good Partner in Biology Research

SSTR5

SSTR5,即生長抑素受體5,別名生長抑素受體亞型5、SS5-R、Somatostatin receptor type 5等。SSTR5是一種G蛋白偶聯受體(GPCRs),主要在垂體中高度表達,參與調控多種激素的分泌,如促腎上腺皮質激素、催乳素和生長激素等。SSTR5的作用機制涉及到與其天然配體生長抑素(SST)或合成激動劑藥物如奧曲肽(octreotide)結合,進而抑制腺苷酸環化酶(AC)的活性,通過抑制性G蛋白(Gi)介導,調控胞內cAMP濃度,影響激素的分泌和腫瘤生長等過程 。SSTR5在生物學上的意義主要體現在其作為多種內分泌疾病和腫瘤治療的潛在靶點。SSTR5的激活可以減少膽囊收縮,增加膽固醇性膽結石的風險,因此,拮抗SSTR5可能會促進膽囊排空,減少膽囊結石的形成 。此外,SSTR5的表達水平與某些癌癥的發病有關,例如研究發現SSTR5基因的變異與頭頸部癌、肺癌、前列腺癌和腎癌等癌癥的發病有關 。因此,SSTR5不僅在調控激素分泌和腫瘤生長中發揮重要作用,也是藥物開發和疾病治療中的潛在靶點。

熱銷產品

Recombinant Human Somatostatin receptor type 5 (SSTR5), partial (CSB-EP022728HU1)

驗證數據

CSB-EP022728HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SSTR5 Antibody (CSB-PA254587)

驗證數據

CSB-PA254587

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA254587(SSTR5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA254587

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA254587(SSTR5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA254587

Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Mouse thymus tissue, Primary antibody: CSB-PA254587(SSTR5 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds

SSTR5 Antibodies

SSTR5 for Homo sapiens (Human)

SSTR5 Proteins

SSTR5 Proteins for Rattus norvegicus (Rat)

SSTR5 Proteins for Homo sapiens (Human)

SSTR5 Proteins for Mus musculus (Mouse)