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Your Good Partner in Biology Research

ROS1

ROS1,即c-ros肉瘤致癌因子-受體酪氨酸激酶,別名CD74-ROS1、EZR-ROS1、SLC34A2-ROS1等,這些別名通常表示ROS1基因與其他基因發生融合的形式。ROS1基因定位于人類6號染色體長臂,屬于酪氨酸激酶胰島素受體基因,由胞內激酶區、跨膜區及胞外區三部分組成,編碼具有酪氨酸激酶活性的跨膜蛋白 。ROS1的作用機制涉及其作為細胞表面受體的功能,當接收到外部特定信息后活化,并傳遞信號到細胞內部,指導細胞有序地生長和增殖。若ROS1基因發生致癌變異,會激活其下游通路的信號,造成細胞過度地生長及增殖,驅動腫瘤的發生。ROS1主要參與的信號通路包括RAS-RAF-MEK-ERK(MAPK)、PI3K-AKT-mTOR等 。在生物學意義上,ROS1基因融合在多種腫瘤中被認為是致癌因素,特別是在非小細胞肺癌中,ROS1融合基因型肺癌的發病率較低,但具有獨特的臨床病理特征。ROS1融合基因的發現為靶向治療提供了新的治療靶點,已有多種針對ROS1的小分子抑制劑在臨床試驗中顯示出療效,如克唑替尼等 。

熱銷產品

ROS1 Antibody (CSB-PA020072LA01HU)

驗證數據

CSB-PA020072LA01HU

Immunofluorescence staining of Hela cells with CSB-PA020072LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ROS1 Antibodies

ROS1 for Homo sapiens (Human)

ROS1 for Arabidopsis thaliana

ROS1 Proteins

ROS1 Proteins for Homo sapiens (Human)

ROS1 Proteins for Gallus gallus (Chicken)

ROS1 Proteins for Rattus norvegicus (Rat)

ROS1 Proteins for Mus musculus (Mouse)

ROS1 Proteins for Arabidopsis thaliana (Mouse-ear cress)