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RORC

RORC,全稱為RAR related orphan receptor C,常見別名包括NR1F3、RORG、RZRG和TOR。該蛋白屬于核受體超家族中的ROR基因家族,參與晝夜節(jié)律、免疫調(diào)節(jié)、代謝和發(fā)育等過程。RORC蛋白在免疫細(xì)胞中發(fā)揮重要作用,特別是Th17細(xì)胞的分化和功能調(diào)控。研究發(fā)現(xiàn),RORC蛋白的表達(dá)與自身免疫性疾病密切相關(guān),如多發(fā)性硬化、銀屑病和類風(fēng)濕關(guān)節(jié)炎等。此外,RORC蛋白還參與淋巴器官發(fā)育和腸道免疫穩(wěn)態(tài)的維持。由于RORC蛋白在疾病發(fā)生發(fā)展中的作用,已成為研究的熱點(diǎn),相關(guān)藥物研發(fā)也在進(jìn)行中,例如開發(fā)針對RORC蛋白的反向激動劑,以治療自身免疫性疾病。

熱銷產(chǎn)品

Recombinant Human Nuclear receptor ROR-gamma (RORC) (CSB-EP020071HU)

驗(yàn)證數(shù)據(jù)

CSB-EP020071HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP020071HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP020071HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RORC.

CSB-EP020071HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP020071HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RORC.

RORC Antibody (CSB-PA020071LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA020071LA01HU

Western Blot
Positive WB detected in: HepG2 whole cell lysate
All lanes: RORC antibody at 5.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 59, 56 kDa
Observed band size: 59 kDa

CSB-PA020071LA01HU

Western Blot
Positive WB detected in: HT29 whole cell lysate, MCF7 whole cell lysate, Jurkat whole cell lysate, HepG2 whole cell lysate
All lanes: RORC antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 59, 56 kDa
Observed band size: 59 kDa

CSB-PA020071LA01HU

IHC image of CSB-PA020071LA01HU diluted at 1:1000 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

CSB-PA020071LA01HU

IHC image of CSB-PA020071LA01HU diluted at 1:1000 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

CSB-PA020071LA01HU

IHC image of CSB-PA020071LA01HU diluted at 1:1000 and staining in paraffin-embedded mouse liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

Human Nuclear receptor ROR-gamma(RORC) ELISA kit (CSB-EL020071HU)

驗(yàn)證數(shù)據(jù)

CSB-EL020071HU 標(biāo)準(zhǔn)曲線

貨號:CSB-EL020071HU

規(guī)格:96T/48T

靈敏度:3.12 pg/mL

檢測范圍:12.5 pg/mL-800 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

RORC Antibodies

RORC for Homo sapiens (Human)

RORC Proteins

RORC Proteins for Homo sapiens (Human)

RORC Proteins for Mus musculus (Mouse)

RORC Proteins for Pongo abelii (Sumatran orangutan)

RORC ELISA Kit

RORC ELISA Kit for Homo sapiens (Human)