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  4. Recombinant Mouse SUN domain-containing protein 5 (Sun5)

Recombinant Mouse SUN domain-containing protein 5 (Sun5)

  • 中文名稱：
    小鼠Sun5重組蛋白
  • 貨號：
    CSB-CF863562MO
  • 規格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
    Sun5
  • Uniprot No.：
  • 別名：
    Sun5; Spag4l; SUN domain-containing protein 5; Sperm-associated antigen 4-like protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-348
  • 氨基酸序列
    MPRTRNIGALCTLPEDTTHSGRPRRGVQRSYISRMAEPAPANMTWLTYLACFLRTQTQQV FLNTCRCKLFCQKVMEKMGLLVLCVFGFWMFSMHLPSKVEVWQDDSINGPLQSLRMYQEK VRHHTGEIQDLRGSMNQLIAKLQKMEAISDEQKMAQKIMKMIQGDYIEKPDFALKSIGAS IDFEHTSATYNHDKARSYWNWIRLWNYAQPPDVILEPNVTPGNCWAFASDRGQVTIRLAQ KVYLSNITLQHIPKTISLSGSLDTAPKDFVIYGLESLPREEVFLGAFQFQPENIIQTFQL QNLPPRSFAAVKVKISSNWGNPRFTCMYRVRVHGSVTPPKDSHLEPLS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.
  • 基因功能參考文獻：
    1. These studies reveal the essential role of SUN5 in anchoring sperm head to the tail and provide a promising way to treat this kind of acephalic spermatozoa-associated male infertility. PMID: 28945193
    2. In Dpy19l2 knock-out round spermatids, the detachment of the acrosome leads to Sun5 and lamin B1 relocalization, confirming that Sun5 protein is excluded from the nuclear envelope facing the acrosome. PMID: 25775128
    3. SPAG4L may play an important role in the meiotic stage of spermatogenesis PMID: 21711156
    4. SPAG4L-2 and SPAG4L are transmembrane proteins that localize to the nuclear envelope. PMID: 21159740
    5. SRG4 was cloned into pUCm-T vectors and sequenced, subcloned into a prokaryotic expression vector and expression of induced by IPTG. PMID: 17618558
    6. Results indicated that the expression of SRG4 was regulated by development, and SRG4 was mainly expressed in the cytoplasm of spermatocytes and round spermatids. PMID: 17650487

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  • 亞細胞定位：
    Nucleus inner membrane; Single-pass membrane protein. Golgi apparatus.
  • 組織特異性：
    Testis-specific, abundantly expressed in spermatocytes and round spermatids.
  • 數據庫鏈接：

    KEGG: mmu:76407

    UniGene: Mm.33629