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  4. Recombinant Human Type-1 angiotensin II receptor-associated protein (AGTRAP)

Recombinant Human Type-1 angiotensin II receptor-associated protein (AGTRAP)

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  • 中文名稱：
    Recombinant Human Type-1 angiotensin II receptor-associated protein(AGTRAP)
  • 品名簡稱：
    Recombinant Human AGTRAP protein
  • 貨號：
    CSB-CF744194HU
  • 說明書：
  • 規格：
    ￥9720
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    AGTRAP
  • Uniprot No.：
  • 別名：
    AGTRAP; ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    in vitro E.coli expression system
  • 分子量：
    37.4 kDa
  • 表達區域：
    1-159aa
  • 氨基酸序列
    MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
  • 基因功能參考文獻：
    1. A role for AT1 receptor-associated proteins in blood pressure regulation PMID: 25562590
    2. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function. PMID: 23902639
    3. The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein). PMID: 21728994
    4. the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock. PMID: 21423001
    5. CSF angiotensin II, ACE, and ACE2 levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 antibody, reflecting severe destruction of perivascular astrocytes PMID: 20541774
    6. Endogenous increases in angiotensin II during dehydration contribute to dehydration-associated sympathoexcitation. PMID: 19805740
    7. Small interfering RNA significantly attenuates angiotensin II type 1 receptor-stimulated inositol phosphate formation. PMID: 20018811
    8. cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein PMID: 11733189
    9. isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK-293 cells PMID: 14559250
    10. mRNA is detected in all human tissues; cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells. PMID: 14985364
    11. CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology PMID: 15668245

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
  • 組織特異性：
    Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
  • 數據庫鏈接：

    HGNC: 13539

    OMIM: 608729

    KEGG: hsa:57085

    STRING: 9606.ENSP00000319713

    UniGene: Hs.464438