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  4. Recombinant Dictyostelium discoideum P2X receptor A (p2xA)

Recombinant Dictyostelium discoideum P2X receptor A (p2xA)

  • 中文名稱：
    盤基網(wǎng)柄菌p2xA重組蛋白
  • 貨號(hào)：
    CSB-CF773000DKK
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    p2xA
  • Uniprot No.：
  • 別名：
    p2xA; DDB_G0272004; P2X receptor A; DdP2X; P2XA
  • 種屬：
    Dictyostelium discoideum (Slime mold)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-378
  • 氨基酸序列
    MGFSFDWDDIFQYSTVKIVRIRDRRLGILHLSFLVGIVAYIVVYSAIIKKGYLFTEVPIG SVRTSLKGPNTFASNLTYCSNQQHNGSTYPFTPLECNYWDEQLALFPVGQDSTFTCTTRV RLSKQEANCNFTDPTCKFVDEPGSAKNIYIADIESFTILIDHTMYASSSGSQFNAVDLHG YILNQDGDEVQIDANGTSIGVSGKPDIMTIGQLLSFGGVSLDQASPVDSNVSIRYDGVVL FVFITYSNTYTYSTSDFKYVYSVQQIANTIYDVPETIILESIHSRLLYKRHGIRVIFIQT GTIGSFHFQTLLLTLVSGLGLLAVATTVVDQLAIRLLPQRKSYSSLKFQVTESMSNPMKK RITTDEGEDVLYTRIEGL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not essential for osmoregulation, however this information is in contradiction with another source which indicates that p2xA is required for osmoregulation. Found to be permeable to chloride ions. Inhibited by copper and sodium ions.
  • 基因功能參考文獻(xiàn)：
    1. P2X receptors localized on intracellular membranes in D. discoideum, are required for osmoregulation. PMID: 17625565
  • 亞細(xì)胞定位：
    Contractile vacuole membrane. Note=Ligand binding domain within the lumen of the vacuole.
  • 蛋白家族：
    P2X receptor family
  • 數(shù)據(jù)庫鏈接：