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  4. Recombinant Mouse Angiopoietin-4 (Angpt4)

Recombinant Mouse Angiopoietin-4 (Angpt4)

  • 中文名稱：
    Recombinant Mouse Angiopoietin-4(Angpt4)
  • 貨號：
    CSB-YP894841MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Angiopoietin-4(Angpt4)
  • 貨號：
    CSB-EP894841MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Angiopoietin-4(Angpt4)
  • 貨號：
    CSB-EP894841MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Angiopoietin-4(Angpt4)
  • 貨號：
    CSB-BP894841MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Angiopoietin-4(Angpt4)
  • 貨號：
    CSB-MP894841MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Angpt4; Agpt4; Ang3Angiopoietin-4; ANG-4; Angiopoietin-3; ANG-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    22-509
  • 氨基酸序列
    QHRGPEAGG HRQIHQVRRG QCSYTFVVPE PDICQLAPTA APEALGGSNS LQRDLPASRL HLTDWRAQRA QRAQRVSQLE KILENNTQWL LKLEQSIKVN LRSHLVQAQQ DTIQNQTTTM LALGANLMNQ TKAQTHKLTA VEAQVLNQTL HMKTQMLENS LSTNKLERQM LMQSRELQRL QGRNRALETR LQALEAQHQA QLNSLQEKRE QLHSLLGHQT GTLANLKHNL HALSSNSSSL QQQQQQLTEF VQRLVRIVAQ DQHPVSLKTP KPVFQDCAEI KRSGVNTSGV YTIYETNMTK PLKVFCDMET DGGGWTLIQH REDGSVNFQR TWEEYKEGFG NVAREHWLGN EAVHRLTSRT AYLLRVELHD WEGRQTSIQY ENFQLGSERQ RYSLSVNDSS SSAGRKNSLA PQGTKFSTKD MDNDNCMCKC AQMLSGGWWF DACGLSNLNG IYYSVHQHLH KINGIRWHYF RGPSYSLHGT RMMLRPMGA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
  • 基因功能參考文獻：
    1. Ang-4 also promoted survival of LECs. Thus, blocking Ang-4 may prune the draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular permeability. PMID: 25977256
    2. Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates cAMP signaling in adipocytes PMID: 22267746
    3. Angiopoietin-3 binds to the cell membrane via heparan sulfate proteoglycans PMID: 15280392
    4. Recombinant Ang3 formed disulfide-linked dimers. Ang3 was more potent than Ang4 in phosphorylating Akt in primary cultured mouse lung microvascular endothelial cells. It is a Tie2 agonist & causes corneal angiogenesis. PMID: 15284220
    5. angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure PMID: 16790085

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：