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  2. 蛋白
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  4. Recombinant Human Lens fiber membrane intrinsic protein (LIM2), partial

Recombinant Human Lens fiber membrane intrinsic protein (LIM2), partial

  • 中文名稱：
    人LIM2重組蛋白
  • 貨號(hào)：
    CSB-YP012946HU1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LIM2重組蛋白
  • 貨號(hào)：
    CSB-EP012946HU1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LIM2重組蛋白
  • 貨號(hào)：
    CSB-EP012946HU1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LIM2重組蛋白
  • 貨號(hào)：
    CSB-BP012946HU1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LIM2重組蛋白
  • 貨號(hào)：
    CSB-MP012946HU1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LIM2
  • Uniprot No.：
  • 別名：
    LIM2; Lens fiber membrane intrinsic protein; MP18; MP19; MP20
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
  • 基因功能參考文獻(xiàn)：
    1. A novel missense mutation in LIM2 is responsible for autosomal recessive congenital cataracts. PMID: 27814360
    2. we report the absence of mutations in all studied genes in four families with phenotypes associating cataract, mental retardation and microcephaly. PMID: 22103961
    3. The genetic mutation in GJA3, GJA8, and LIM2 may slightly contribute to the development of age-related cataracts. PMID: 21386927
    4. Since the LIM2 gene promoter does not contain a classic TATA box, the Hsu element may serve as the site for binding the RNA polymerase complex. PMID: 15968979
    5. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family PMID: 11917274
    6. This study shows the involvement of LIM2 in human congenital cataract. PMID: 18596884

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  • 相關(guān)疾病：
    Cataract, multiple types 19 (CTRCT19)
  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PMP-22/EMP/MP20 family
  • 組織特異性：
    Eye lens specific.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6610

    OMIM: 154045

    KEGG: hsa:3982

    UniGene: Hs.162754