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  4. Recombinant Human Glutamate [NMDA] receptor subunit 3B (GRIN3B), partial

Recombinant Human Glutamate [NMDA] receptor subunit 3B (GRIN3B), partial

  • 中文名稱：
    人GRIN3B重組蛋白
  • 貨號：
    CSB-YP009917HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GRIN3B重組蛋白
  • 貨號：
    CSB-EP009917HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GRIN3B重組蛋白
  • 貨號：
    CSB-EP009917HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GRIN3B重組蛋白
  • 貨號：
    CSB-BP009917HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GRIN3B重組蛋白
  • 貨號：
    CSB-MP009917HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    GluN3B; Glutamate [NMDA] receptor subunit 3B; Glutamate receptor ionotropic N methyl D aspartate 3B ; Glutamate receptor ionotropic NMDA 3B; GRIN3B; N-methyl-D-aspartate receptor subtype 3B; NMD3B_HUMAN; NMDA receptor subunit 3B; NMDA type glutamate receptor subunit NR3B; NMDAR3B; NR3B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

相關產品

靶點詳情

  • 功能：
    NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
  • 基因功能參考文獻：
    1. GRIN3B missense mutation is an inherited risk factor for schizophrenia. PMID: 28132660
    2. Authors investigated the significance of a common human genetic variation of the NMDAR NR3B subunit PMID: 25768306
    3. Rs2240158 of GRIN3B was significantly associated with mismatch negativity in healthy subjects. PMID: 24814139
    4. our findings suggest that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of chronic opioid abuse. PMID: 20153313
    5. These observations suggest that the genetic variation of the NR3B subunit of the NMDA receptor is not a risk factor for Alzheimer's dis pathogenesis PMID: 20016182
    6. NR3B mRNA expression in the human hippocampal formation (CA1-CA4 and dentate gyrus) and adjacent neocortex may have implications for understanding the role of NMDA receptors for physiological and pathological processes in these forebrain regions. PMID: 15722182
    7. cross-talk between NR3B and NR4A receptors is a mechanism modulating the transcriptional activities of these orphan nuclear receptors PMID: 17543277
    8. We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). PMID: 17687115

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR3B/GRIN3B subfamily
  • 數據庫鏈接：

    HGNC: 16768

    OMIM: 606651

    KEGG: hsa:116444

    STRING: 9606.ENSP00000234389

    UniGene: Hs.660378