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  4. FKBP8 Recombinant Monoclonal Antibody

FKBP8 Recombinant Monoclonal Antibody

  • 中文名稱：
    FKBP8 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA585704A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of FKBP8 expression in HepG2 cells using FKBP8 antibody. Green, isotype control; red, FKBP8.
    • Immunocytochemical staining of HepG2 cells with FKBP8 antibody. Nuclei were stained blue with DAPI; FKBP8 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using FKBP8 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with FKBP8 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    FKBP8
  • 別名：
    FKBP8; FKBP Prolyl Isomerase 8; FKBP38; Peptidyl-Prolyl Cis-Trans Isomerase FKBP8; FK506 Binding Protein 8, 38kDa; 38 KDa FK506-Binding Protein; FK506-Binding Protein 8; PPIase FKBP8; 38 KDa FKBP; Rotamase; FKBPr38; FKBP-38; HFKBP38; FKBPR38; FKBP-8; FK506-Binding Protein 8 (38kD); FK506 Binding Protein 8; EC 5.2.1.8
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human FKBP8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    18B3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
  • 基因功能參考文獻：
    1. Cycling between the inactive GDP- and the active GTP-bound state modulates the backbone dynamics of a C-terminal truncated form, RhebDeltaCT, which is suggested to influence its interactions. We further investigated the interactions between RhebDeltaCT and the proposed Rheb-binding domain of the regulatory protein FKBP38. PMID: 29194576
    2. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90beta as a molecular model for myotonia congenita has been described. PMID: 27580824
    3. Co-expression of FKBP8 with LC3A profoundly induces Parkin-independent mitophagy. Strikingly, even when acting as a mitophagy receptor, FKBP8 avoids degradation by escaping from mitochondria. In summary, this study identifies novel roles for FKBP8 and LC3A, which act together to induce mitophagy. PMID: 28381481
    4. FKBP8 binding to Hsp90 did not substantially influence its ATPase activity PMID: 28278223
    5. The information presented here provides important clues for understanding the catalytic activity of FKBP38, its regulation by the unique N-terminal extension, and the potential calcium- and calmodulin-mediated activation of FKBP38. PMID: 24145868
    6. Overexpression of permanently active S100P in Huh-7 cells inhibited the interaction of FKBP38 with Bcl-2, resulting in the suppression of Bcl-2 stability PMID: 24295050
    7. FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability PMID: 22474283
    8. The derived structure model of the complex between Bcl-2 and the FKBP38 catalytic domain features both electrostatic and hydrophobic intermolecular contacts and provides a rationale for the regulation of the FKBP38/Bcl-2 interaction by Ca(2+). PMID: 22523079
    9. Data support a dual role for FKBP38 in regulating CFTR synthesis and post-translational folding. PMID: 22030396
    10. a dual mechanism for PA activation of mTORC1: PA displaces FKBP38 from mTOR and allosterically stimulates the catalytic activity of mTORC1. PMID: 21737445
    11. this charge-sensitive site in the FKBP domain participates in the regulation of FKBP38 function by enabling electrostatic interactions with ligand proteins and/or salt ions such as Ca(2+) PMID: 20140889
    12. novel insights into the structural arrangement of FKBP38/calmodulin complex PMID: 20707607
    13. FKBP38 is a key player in regulating the function of Bcl-2 by antagonizing caspase-dependent degradation through the direct interaction with the flexible loop domain of Bcl-2, which contains the caspase cleavage site PMID: 20139069
    14. Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL PMID: 20048149
    15. FKBP38 plays a role in TSC gene-dependent cell size regulation. PMID: 12894220
    16. Bcl-2 interacts with FKBP38 through the unstructured loop, and the interaction appears to regulate phosphorylation in the loop of Bcl-2 PMID: 15733859
    17. FKBP38 indirectly affects the subcellular distribution of calcineurin by interaction with typical calcineurin ligands, as exemplified by the anti-apoptotic protein Bcl-2. PMID: 15757646
    18. Molecular model of the FK506-binding domain of FKBP38. PMID: 16604427
    19. the complex consisting of NS5A, FKBP8, and Hsp90 plays an important role in HCV RNA replication PMID: 17024179
    20. Data suggest that the peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. PMID: 17353276
    21. FKBP38 is a co-chaperone of HERG and contributes via the Hsc70/Hsp90 chaperone system to the trafficking of wild type and mutant HERG potassium channels PMID: 17569659
    22. FKBP38 functions to anchor the 26S proteasome at the organellar membrane PMID: 17573772
    23. interaction between the catalytic FKBP38 domain and the N-terminal CaM domain activates FKBP38 and, as a consequence, also regulates Bcl-2. PMID: 17942410
    24. findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability PMID: 17991864
    25. These results suggest that specific interaction of NS5A with FKBP8 in the cytoplasmic compartment plays a crucial role in the replication of HCV. PMID: 18216108
    26. FKBP38 is a bona fide effector of Rheb and the ability to interact with FKBP38 is important for Rheb as an activator of mTOR PMID: 18658153
    27. neither TCTP nor FKBP38 regulates mTORC1 signaling. PMID: 18676370
    28. FKBP38 plays only a very minor, if any, role in mTORC1 activation. PMID: 19222999
    29. Data indicate that PHD2 protein stability is regulated by a ubiquitin-independent proteasomal pathway involving FKBP38 as adaptor protein that mediates proteasomal interaction. PMID: 19546213

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  • 亞細胞定位：
    Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.; [Isoform 1]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.; [Isoform 3]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.
  • 組織特異性：
    Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.
  • 數據庫鏈接：

    HGNC: 3724

    OMIM: 604840

    KEGG: hsa:23770

    STRING: 9606.ENSP00000222308

    UniGene: Hs.173464