日韩在线视频不卡-日一区二区三区-天堂国产+人+综合+亚洲欧美-精品国产一区二区三区久久狼-国产成人无码18禁午夜福利网址-国产在线拍偷自揄拍精品-九色91丨porny丨丝袜-久久天天躁狠狠躁夜夜av-99蜜桃臀久久久欧美精品-成人一区二区视频-狠狠操人人干-40岁干柴烈火少妇高潮不断-国产福利不卡-伊人98-丰满多毛的陰户视频-日韩一二三四五区-国产专区一线二线三线码-好男人社区影院www-国产精品2019-欧美三级一区

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NAA15 Antibody

NAA15 Antibody

  • 中文名稱：
    NAA15兔多克隆抗體
  • 貨號：
    CSB-PA058433
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HUVEC cells, using NARG1 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NAA15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NAA15
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human NARG1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.
  • 基因功能參考文獻：
    1. individuals with copy-number variant (CNV) deletions involving NAA15 and surrounding genes can present with mild intellectual disability, mild dysmorphic features, motor delays, and decreased growth. PMID: 29656860
    2. In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
    3. Authors highlight NAA15 as a novel candidate ID gene based on the vital role of NAA15 in the generation and differentiation of neurons in neonatal brain. PMID: 28990276
    4. Human Naa15 (NATH) and Naa10 (ARD1) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH) and Naa10 (ARD1) are cleaved during apoptosis resulting in decreased acetyltransferase activity PMID: 15496142
    5. Development of the first N-terminal acetyltransferase (NAT) inhibitors, including inhibitors to the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH). PMID: 23557624
    6. Protein N-terminal acetyltransferases (NATs), including the NatA complex composed of Naa10 (ARD1) and Naa15 (NATH), act as N-terminal propionyltransferases. PMID: 23043182
    7. Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation. PMID: 20154145
    8. NATH, a novel gene overexpressed in papillary thyroid carcinomas. PMID: 12140756
    9. description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein PMID: 15496142
    10. levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures PMID: 16279846
    11. Loss of retinal endothelial Tbdn-1 expression may be a contributing factor in retinal blood vessel proliferation in retinopathy of prematurity. PMID: 16518308
    12. Essential role in cell survival through protein N-alpha-acetylation. PMID: 16518407
    13. NATH complexes with hARD1 in a ribosomal associated protein-N-acetyltransferase complex. PMID: 15496142

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
  • 組織特異性：
    Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, u
  • 數據庫鏈接：

    HGNC: 30782

    OMIM: 608000

    KEGG: hsa:80155

    STRING: 9606.ENSP00000296543

    UniGene: Hs.745047