Recombinant Human Persephin protein (PSPN), partial (Active)

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產品詳情

純度：

>97% as determined by SDS-PAGE.
內毒素：

Less than 1.0 EU/μg as determined by LAL method.
生物活性：

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TT medullary thyroid cancer cells is less than 10 ng/ml, corresponding to a specific activity of >1.0x10⁵ IU/mg.
基因名：

PSPN
Uniprot No.：

O60542
別名：

PSPN; Persephin; PSP
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

E.Coli
分子量：

10.3 kDa
表達區域：

61-156aa
氨基酸序列

ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
蛋白標簽：

Tag-Free
產品提供形式：

Liquid or Lyophilized powder
緩沖液：

0.2 μm filtered PBS, pH 7.4 ,lyophilized
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

5-10 business days
Datasheet & COA：

Please contact us to get it.

功能：

Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
基因功能參考文獻：
1. Results suggested that PSPN is a possible key regulator of oral squamous cell carcinoma (OSCC) progression via PSPN-RET-mitogen-activated protein kinase activation and that PSPN overexpression may have diagnostic potential for OSCC. PMID: 24375483
2. Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex. PMID: 20350599
3. Persephin/GFRalpha4 is unable to recruit RET protein into lipid rafts. PMID: 15225646
4. The results obtained suggest the involvement of NTN, PSP, and ART in processes subserving both the organization of this cortical region during development and the functional activity and maintenance of the mature human hippocampal neurons. PMID: 15829225
5. No differences were found in the allelic frequencies of the variants or in the haplotype distribution between Hirschsprung's disease patients & controls, nor to any demographic/clinical parameters within the group of patients. PMID: 18970938
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亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family, GDNF subfamily
數據庫鏈接：

HGNC: 9579

OMIM: 602921

KEGG: hsa:5623

STRING: 9606.ENSP00000245810

UniGene: Hs.248159